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Preheat oven to 350°F. Spray 2 9-inch round cake pans with Baker's Joy spray.
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Beat cake mix, eggs, beer, and oil in large bowl with electric mixer on low speed until blended. Increase speed to medium and beat 2 minutes. Pour batter into prepared pans.
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Bake 22 to 26 minutes or cake springs back when lightly touched in center. Cool on wire racks for 10 minutes. Remove cakes from pans and cool completely.
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To make frosting, beat butter with sugar in a large bowl with electric mixer until light and fluffy. Beat in Irish cream liquor and vanilla. Slowly beat in heavy cream and beat until light and fluffy.
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Place 1 cake layer on serving plate, spread 3/4 cup frosting over top of cake. Place remaining layer on top and frost top and sides of cake with remaining frosting. Refrigerate until ready to serve.